NCT05451121

Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery

Comparing Effect of Propofol, Dexmedetomidine and Their Combination on Duration Mechanical Ventilation in Patient After Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 356 (actual)
• Sponsor: Anesthesia Research Group UA · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

There is a direct relationship between the sedative agent and the duration of ventilation.

Detailed description

Sedation and sedative agent have direct correlation to the mechanical length. As known mechanical length could increase length of the hospital stay (LOHS) and mortality rate. The right sedative agent can decrease the length go the mechanical ventilation. The goal of the research to compare 3 sedation strategies and their influence to the duration of mechanical ventilation.

Conditions

• Respiratory Failure
• Mechanical Ventilation Complication
• Sedation Complication

Interventions

Type	Name	Description
DRUG	Propofol	patient sedation with a propofol (sedative agent) after cardiac surgery
DRUG	Dexmedetomidine	patient sedation with dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist) after cardiac surgery
DRUG	Propofol and dexmedetomidine	Patients sedation with a drug combination: propofol and dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist)

Timeline

• Start date: 2017-07-01
• Primary completion: 2019-07-01
• Completion: 2019-07-01
• First posted: 2022-07-11
• Last updated: 2022-07-11

Locations

1 site across 1 country: Ukraine