NCT05400239

SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome

SOTO Study: Prospective Study to Correlate the Treatment Sensitivity of Patient-derived Organoids With Clinical Outcomes in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Guy's and St Thomas' NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

In this study, we aim to assess whether Patient Derived Organoids can be used to predict treatment sensitivity in HNSCC patients.

Detailed description

This is a prospective observation study to generate patient-derived organoids from patients' samples to assess treatment response and to correlate with patients' treatment outcomes and to collect preliminary data on the ability of PDOs to predict patients' treatment response and whether their radiosensitivity and chemosensitivity can be correlated with their survival outcome.

Conditions

• Head and Neck Squamous Cell Carcinoma
• Head and Neck Cancer

Timeline

• Start date: 2022-06-01
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2022-06-01
• Last updated: 2024-03-21

Locations

1 site across 1 country: United Kingdom