Trials / Completed
CompletedNCT05330676
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
The MicroRESUS Study: An Observational Study to Examine the Effects of Circulatory Shock and Resuscitation on Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 142 (actual)
- Sponsor
- University of Pennsylvania · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
Detailed description
Post-cardiotomy shock (PCS) occurs in up to 5% of cardiovascular surgeries and has an in-hospital mortality rate as high as 75%. It is unclear if patients with PCS despite achieving standard resuscitation goals have impairments in oxygen delivery or oxygen utilization. This study will examine the difference in microcirculatory function and mitochondrial respiration in patients with shock to better understand the driving mechanism of bioenergetic failure in patients with PCS.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | coronary artery bypass grafting, valve repair/replacement | cardiovascular surgery with cardiopulmonary bypass |
Timeline
- Start date
- 2020-09-01
- Primary completion
- 2023-04-01
- Completion
- 2023-04-01
- First posted
- 2022-04-15
- Last updated
- 2024-05-02
- Results posted
- 2024-05-02
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05330676. Inclusion in this directory is not an endorsement.