NCT05246813

Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP): a Prospective Observational Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 24 (estimated)
• Sponsor: Imelda Hospital, Bonheiden · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Not accepted

Summary

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

Conditions

• Osteoporosis
• Osteoarthritis, Hip
• Hip Fractures
• Clonal Hematopoiesis of Indeterminate Potential
• Aging

Interventions

Type	Name	Description
OTHER	Blood and bone marrow cell collection	Collection of blood and bone marrow

Timeline

• Start date: 2022-02-11
• Primary completion: 2028-12-31
• Completion: 2030-12-31
• First posted: 2022-02-18
• Last updated: 2026-03-25

Locations

1 site across 1 country: Belgium