NCT05233501

Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment

The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received Non-surgical Periodontal Treatment.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Beykent · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.

Detailed description

Limited data is available regarding the effects of various periodontal treatment protocols on GCF t-PA and PAI-1 levels, and the extent to which LLLT in conjunction with NSPT affects these levels in patients with Stage 3-4, Grade C periodontitis is unknown. Therefore, this study measured standard clinical outcomes and GCF t-PA and PAI-1 levels in patients with Stage 3-4 Grade, C periodontitis in order to assess the use of LLLT as an adjunct to standard NSPT. This split-mouth study was conducted with 15 Stage 3-4, Grade C periodontitis patients and 15 healthy individuals matched for age and sex. Participants were grouped as follows: Periodontitis/NSPT (Sham); Periodontitis/NSPT+LLLT (LLLT); Periodontally Healthy (Control). LLLT was applied following NSPT and again on post-treatment Days 2 and 7. Clinical parameters were recorded at baseline (i.e. before NSPT) and on Day 30. Gingival crevicular fluid (GCF) samples were collected at baseline and during follow-up visits on Days 7, 14 and 30. GCF t-PA and PAI-1 levels were measured with ELISA.

Conditions

• Periodontal Diseases
• Periodontal Attachment Loss
• Periodontal Disease, AVDC Stage 3
• Periodontal Inflammation
• Periodontal Disease, AVDC Stage 4

Interventions

Type	Name	Description
PROCEDURE	low level laser therapy	adjunctive application of low level laser therapy to non-surgical periodontal treatment
PROCEDURE	non-surgical periodontal treatment	standart periodontal therapy

Timeline

• Start date: 2017-01-01
• Primary completion: 2017-09-30
• Completion: 2018-08-30
• First posted: 2022-02-10
• Last updated: 2022-02-10

Locations

1 site across 1 country: Turkey (Türkiye)