NCT05152875

Relationship Between Fungal Colonization and Severe Bronchopulmonary Dysplasia

Relationship Between Fungal Colonization and Severe Bronchopulmonary Dysplasia: Myth or Reality? Retrospective Study of Premature Infants Inferior to 29 Weeks of Gestation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 153 (actual)
• Sponsor: Centre Hospitalier Sud Francilien · Academic / Other
• Sex: All
• Age: 1 Day – 29 Days
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine if fungal colonization is associated to severe bronchopulmonary dysplasia in premature infants less than 29 weeks of gestation, and to determine if an association exists between fungal colonization and complications of prematurity and death.

Detailed description

Fungal colonization is common in premature infants. Certain neonatal departments, routinely screen for fungal colonization by weekly cultures, while other departments perform fungal cultures solely in the presence of suggestive clinical or biological signs such as hyperleucocytosis, maternal vaginal candidiasis, sepsis and characteristic skin lesions. This neonatal colonization can progress to an invasive fungal infection leading to death and comorbidities. A relationship between fungal colonization and severe bronchopulmonary dysplasia is suspected.

Conditions

• Bronchopulmonary Dysplasia
• Extreme Prematurity
• Fungal Infection

Interventions

Type	Name	Description
OTHER	biological	fungal colonization by weekly cultures

Timeline

• Start date: 2022-03-21
• Primary completion: 2022-05-31
• Completion: 2022-05-31
• First posted: 2021-12-10
• Last updated: 2024-11-26

Locations

1 site across 1 country: France