NCT05108649

Impact of Nicotine Messaging on Beliefs and Behavior

Study 2: Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Andrew Strasser · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the effect of nicotine messaging and nicotine content of study cigarettes on nicotine beliefs and subsequent use of tobacco and nicotine products.

Detailed description

This project will utilize a randomized, factorial design trial to examine the effects of nicotine messaging on nicotine harm beliefs and smoking behavior. After a 7-day period of smoking own preferred brand cigarettes, participants will begin a 28-day experimental period and will be randomized to one of four conditions: 1) Nicotine Corrective Messaging (NCM) + Reduced nicotine content (RNC) cigarettes, 2) NCM + normal nicotine content (NNC) cigarettes, 3) Delayed Control Messaging + RNC cigarettes, or 4) Delayed Control Messaging + NNC cigarettes. The investigators will aim to recruit and randomize 160 current, daily cigarette smokers (80 male, 80 female) in a 35-day protocol. Participants will be asked to attend 6 in-person sessions at the Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) on Days 0, 7, 14, 21, 28 \& 35. Sessions will occur every 6-8 days.

Conditions

• Smoking Behaviors
• Cigarette Smoking

Interventions

Type	Name	Description
OTHER	Nicotine Messaging	After completing a 7-day baseline period, participants will be randomized to a 28-day experimental period and will view nicotine corrective messaging at each in-person session or delayed control messaging at the final study session.
OTHER	Cigarette Condition	After completing a 7-day period of smoking own brand cigarettes, participants will be randomized to a 28-day experimental period and will receive reduced nicotine content (RNC) cigarettes or normal nicotine content (NNC) cigarettes.

Timeline

• Start date: 2022-03-02
• Primary completion: 2024-06-20
• Completion: 2024-06-20
• First posted: 2021-11-05
• Last updated: 2025-12-08
• Results posted: 2025-12-08

Locations

1 site across 1 country: United States