NCT05084924

Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can increase goal-directed behavior in participants with major depressive disorder and elevated symptoms of anhedonia.

Detailed description

The purpose of this clinical trial is to investigate the causal role that delta-beta coupling plays in goal-directed behavior in participants with major depressive disorder (MDD) and symptoms of anhedonia. The participants will perform a reward-based decision-making task. During the task, cross-frequency transcranial alternating current stimulation (tACS) will be delivered at delta-beta frequency, a control-frequency, or an active sham. Electroencephalography will be collected in intermittent resting-state periods. Structural and functional magnetic resonance imaging (MRI) will be collected during the resting-state and during performance of the task.

Conditions

• Major Depressive Disorder
• Anhedonia

Interventions

Type	Name	Description
DEVICE	Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus	Stimulation will be delivered via the NeuroConn Direct Current Stimulator Plus, an investigational electrical non-invasive brain stimulation device that is being used for foundational neuroscience and translational research.

Timeline

• Start date: 2021-11-02
• Primary completion: 2023-07-31
• Completion: 2023-07-31
• First posted: 2021-10-20
• Last updated: 2024-06-25
• Results posted: 2024-06-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study