NCT04960657

The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

To investigate the hemodynamic effects of PACAP38 after glibenclamide administration.

Detailed description

22 healthy participants will randomly be allocated to receive PACAP38 infusion followed by glibenclamide or placebo on two different days. The aim of the study is to investigate the vascular effect of PACAP38 after glibenclamide administration. Repeated measurements covering the arteria radialis (RA), superficial temporal artery (STA) and middle cerebral artery (MCA) before and after PACAP38 infusion and glibenclamide/placebo administration

Conditions

• Migraine
• Headache
• Pain

Interventions

Type	Name	Description
DRUG	glibenclamide	Oral administration of glibenclamide/placebo. To investigate the role of PACAP38 on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
DRUG	PACAP38	PACAP38 infusion

Timeline

• Start date: 2020-10-20
• Primary completion: 2021-03-19
• Completion: 2021-03-19
• First posted: 2021-07-14
• Last updated: 2021-07-14

Locations

1 site across 1 country: Denmark