NCT04851392

Do Adolescents and Adults Differ in Their Acute Response to Cannabis?

Do Adolescents and Adults Differ in Their Acute Subjective, Behavioural and Neural Responses to Cannabis, With and Without Cannabidiol?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: University College, London · Academic / Other
• Sex: All
• Age: 16 Years – 29 Years
• Healthy volunteers: Accepted

Summary

The acute effects of cannabis may differ between adolescents and adults. Furthermore, these effects may be tempered by the presence of cannabidiol. This double-blind, placebo-controlled, crossover experiment investigates the acute effects of cannabis (with and without cannabidiol) on subjective effects, behavioural responses and neural functioning in 16-17 year-olds and 26-29 year-olds who regularly use cannabis (0.5-3 days per week).

Conditions

• Cannabis
• Cannabis Intoxication
• Cannabis Use
• Cannabis Dependence
• Marijuana
• THC
• CBD
• Adolescent Development

Interventions

Type	Name	Description
DRUG	Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)	Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) - inhaled and vaporised cannabis flower
DRUG	Cannabis with THC without CBD	Cannabis with THC without CBD - inhaled and vaporised cannabis flower
DRUG	Placebo cannabis	Placebo cannabis, without THC and without CBD - inhaled and vaporised

Timeline

• Start date: 2019-03-11
• Primary completion: 2021-06-16
• Completion: 2021-06-16
• First posted: 2021-04-20
• Last updated: 2021-09-29

Locations

1 site across 1 country: United Kingdom