NCT04761965

Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy

Clinical Study of the Sensitivity and Specificity of the Quantitative Assessment of Bone Marrow Cellularity by MRI in Comparison With Trepanobiopsies in Patients With Diseases of the Hematopoietic System

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

Detailed description

The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.

Conditions

• Aplastic Anemia
• Aplastic Anemia Idiopathic

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Bone marrow cellularity by mDixon-quant	if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant

Timeline

• Start date: 2021-02-16
• Primary completion: 2023-12-26
• Completion: 2024-01-01
• First posted: 2021-02-21
• Last updated: 2023-03-08

Locations

1 site across 1 country: Russia