Trials / Unknown
UnknownNCT04617405
Hormonal and Inflammatory Changes During Pregnancy in Women With Glucose Metabolic Disorders.
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (estimated)
- Sponsor
- University of Aarhus · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- —
Summary
The first aim of this study is to describe maternal hormonal and inflammatory changes during pregnancy in women that differ metabolically (limited to women with type 2 diabetes, gestational diabetes and/or overweight). The second aim of this study is to examine maternal hormonal, inflammatory and metabolic factors associated with insulin sensitivity in human pregnancy.
Detailed description
This is a prospective observational study including app. 300 pregnant women from the outpatient clinics at Department of Obstetrics and Gynecology at Aalborg, Odense and Aarhus University Hospital. The study includes 50 healthy normal-weight women, 150 healthy overweight women, 50 women with gestational diabetes and 50 women with type 2 diabetes. Hormonal profiles and inflammatory markers will be measured at gestational week 8-10, 10-14, 18-22, 24-28 and 34-38. The blood samples will include HbA1c, glukose, insulin, C-peptid, lipid profile, liver enzymes, creatinine, FGF-21, TSH, Cortisol, human chorionic gonadotropin, estradiol, progesterone, prolactin, human placental lactogen, placental growth hormone, IGF-1, IGF-BP's, Leptin, Adiponectin, GLP-1, GIP, hs-CRP, IL-6, IL-10, IL-1α, IFN-ɣ, TNF-α, ICAM1, VCAM and CD163. In addition to this, exosomes will be isolated precisely and profiling of the content of exosomes will be performed using in vitro assays. Proteomics and miRNAs sequencing will be employed. Height, weight, and blood pressure will be measured at every visit and a urine sample will be collected. Insulin sensitivity will be estimated using the homeostasis model assessment, IS-HOMA, based on fasting insulin and glucose concentrations.
Conditions
- Diabetes Mellitus, Type 2
- Gestational Diabetes
- Overweight and Obesity
- Pregnancy in Diabetic
- Insulin Resistance
- Insulin Sensitivity
- Pregnancy, High Risk
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | No interventions | No interventions |
Timeline
- Start date
- 2021-01-11
- Primary completion
- 2023-12-01
- Completion
- 2023-12-01
- First posted
- 2020-11-05
- Last updated
- 2022-11-23
Locations
3 sites across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04617405. Inclusion in this directory is not an endorsement.