NCT04531163

Possible Ameliorating Effect of N- Acetylcysteine (NAC) on Type-II Diabetes Induced Nephropathy

Possible Ameliorating Effect of N- Acetylcysteine on Type-II Diabetes Induced Nephropathy

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Accepted

Summary

The study is focused on the possible improving effect of N-acetylcysteine on nephropathy of type-2 diabetic patients. Study design: Prospective clinical based study. The aim of this work is to study the effect of N-acetylcysteine (NAC) on proteinuria and on the serum level of lipoprotein a (LPa) in diabetes induced nephropathy in type-2 diabetic patients.

Detailed description

This study will be carried on 60 participants with Type 2 Diabetes with age over 20 years. Participants will be classified into two groups: 1. Group I (Interventional): treated with (NAC) dose of 1200 mg/day for two months in conjunction with conventional treatment. 2. Group II (Non-interventional): control group receive conventional treatment. All patients will undergo the following: 1. Full medical history will be taken. 2. Laboratory investigations as follows: Blood samples will be collected for analysis after overnight fasting at the beginning and after 2 months of the study for determination of: 1. Total cholesterol (T-chol). 2. Plasma triglycerides (TG). 3. High density lipoprotein cholesterol (HDL-C). 4. Low density lipoprotein cholesterol (LDL-C). 5. Fasting blood sugar. 6. Blood urea nitrogen (BUN). 7. Serum creatinine (SCr). 8. Urine analysis. 9. Glycated hemoglobin (HbA1c). 10. Lipoprotein (a). In addition, blood pressure will be measured for 24 hr.

Conditions

• Diabetic Kidney Disease
• Diabetes Mellitus, Type 2
• Diabetic Nephropathies

Interventions

Type	Name	Description
DRUG	N Acetylcysteine	(NAC) is a drug used in the experiment and participant are treated with it by 1200mg/day dose for two months.

Timeline

• Start date: 2019-10-01
• Primary completion: 2020-11-01
• Completion: 2020-12-01
• First posted: 2020-08-28
• Last updated: 2020-08-28

Locations

1 site across 1 country: Egypt