NCT04463940

Xanthine Oxidase and Uric Acid Origin in Preeclamptic Women

The Origin of Xanthine Oxidase and Its Metabolite, Uric Acid, in Preeclamptic Pregnant Women - A Pilot Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Barzilai Medical Center · Academic / Other
• Sex: Female
• Age: 20 Years – 55 Years
• Healthy volunteers: —

Summary

Findings regarding the presence of xanthine oxidase and uric acid in different blood locations is important in preeclamptic women. We aim to detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations") in pregnant women with and without diagnosis of preeclampsia. The study population will be divided into groups matching the three "locations" in order to describe and compare outcome levels.

Detailed description

Significance - findings regarding the presence of xanthine oxidase and uric acid in different blood locations may provide a scientific basis for understanding the source of them in preeclamptic women. Aim - detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations"). Methods - samples will be collected from pregnant women with and without diagnosis of preeclampsia with blood uric acid \> 6 mg/dL. Than the study population will be divided into groups matching the three "locations". The investigators will describe and compare outcome levels (including Xanthine oxidase, uric acid).

Conditions

• Pre-Eclampsia
• Hyperuricemia

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2020-06-30
• Primary completion: 2023-08-01
• Completion: 2024-08-01
• First posted: 2020-07-09
• Last updated: 2022-07-25

Locations

1 site across 1 country: Israel