NCT04421066

Histological, Genetic and Epigenetic Analysis of Procedures Related with Dental Implants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Simón Pardiñas López · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Accepted

Summary

In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression of peri-implant diseases and prevention of implant failure will be used.

Detailed description

Samples stored at the Biomedical Research Institute of A Coruña, Xerencia Integrated Management of A Coruña (University Hospital Center of A Coruña), belonging to the collection of the line of research "Oral Health and Systemic Relationship" with registration nº 2017/104 will be used for the realization of the present study. Nucleic acid extraction and histological analysis of the samples will be performed to evaluate the functional epigenetic modifications associated with peri-implant diseases, in an exploratory manner.

Conditions

• Peri-Implantitis
• Peri-implant Mucositis
• Implant Complication
• Implant Tissue Failure

Interventions

Type	Name	Description
PROCEDURE	Gingival and bone sample collection	Gingival and bone samples will be collected from the sites affected by peri-implantitis during their surgical treatment of peri-implantitis or histological and epigenetic analysis.
PROCEDURE	Healthy individuals	Gingival and bone samples will be collected from the extraction sites for histological and epigenetic analysis.

Timeline

• Start date: 2019-01-29
• Primary completion: 2021-10-21
• Completion: 2022-06-20
• First posted: 2020-06-09
• Last updated: 2025-02-26

Locations

1 site across 1 country: Spain