Trials / Completed
CompletedNCT04401189
The Role of Circadian Rhythms in Cancer-Related Symptoms
The Role of Circadian Rhythms in Cancer-Related Symptoms: A Prospective Controlled Chrono-Bio-Behavioral Observation Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 124 (actual)
- Sponsor
- Aarhus University Hospital · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer treatment-related symptoms (CRS) such as fatigue, sleep disturbance, cognitive impairment, and depressed mood. Given the detrimental effect of CRS on cancer survivors' quality of life, and a pressing demand for effective interventions to treat CRS, there is a need for a comprehensive examination of circadian disruption related to cancer and its treatment, and its association with CRS. The study will prospectively examine circadian rhythms and a CRS composite score in recently diagnosed breast cancer patients from prior to surgery or chemotherapy to 12 months later. A matched healthy control group will serve as a comparison.
Conditions
- Breast Cancer
- Fatigue
- Cognitive Impairment
- Sleep
- Depression
- Quality of Life
- Stress, Psychological
- Inflammation
- Circadian Rhythm Disorders
- Cancer-Related Syndrome
Timeline
- Start date
- 2020-06-01
- Primary completion
- 2023-06-30
- Completion
- 2023-06-30
- First posted
- 2020-05-26
- Last updated
- 2024-06-28
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04401189. Inclusion in this directory is not an endorsement.