NCT04391634

Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation

Cerebral Oxygenation and Circulatory Parameters During Pressure Controlled vs. Volume Targeted Mechanical Ventilation in the Extremely Preterm Infants With Respiratory Distress Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Poznan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 24 Weeks – 27 Weeks
• Healthy volunteers: Not accepted

Summary

The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.

Detailed description

Prospective, cross-over trial enrolling neonates \<28 weeks' gestation requiring MV. Patients were ventilated for 3 hours with pressure controlled assist-control (PC-AC) mode, followed by 3-hours of volume guarantee assist-control ventilation (VG-AC). Continuous monitoring was carried out using pulse oximetry (oxygen saturation - SpO2 and heart rate - HR), near-infrared spectroscopy (cerebral oxygenation - StO2) and electrical cardiometry (circulatory parameters).

Conditions

• Respiratory Distress Syndrome, Newborn
• Respiratory Failure
• Premature Birth

Interventions

Type	Name	Description
OTHER	volume guarantee	volume guarantee assist-control mechanical ventilation
OTHER	pressure-controlled	pressure-controlled assist-control mechanical ventilation

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-05-30
• Completion: 2018-05-30
• First posted: 2020-05-18
• Last updated: 2020-05-21

Locations

1 site across 1 country: Poland