Trials / Completed
CompletedNCT04382547
Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells
- Status
- Completed
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Other Government
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
Treatment of patients with Covid-19 associated pneumonia using intravenous injection of allogenic pooled olfactory mucosa-derived mesenchymal stem cells
Detailed description
During the implementation of the project, it is planned to develop a method for the treatment of severe covid-19 associated interstitial pneumonia using allogeneic mesenchymal stem cells. The positive outlook for the effectiveness of MSCs is due to the following: * knowledge of the leading role of immunopathogenetic mechanisms in the development of acute interstitial lung diseases and the pronounced immunomodulating properties of MSCs; * high tropism of MSCs to lung tissue when administered intravenously; * the ability of MSCs to stimulate tissue regeneration and the effective use of MSCs in the treatment of acute damage to the myocardium and kidneys, which will contribute to the treatment of multiple organ failure; * positive results of preclinical studies of the method of treatment of viral pneumonia in animals, and the first clinical studies in patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Allogenic pooled olfactory mucosa-derived mesenchymal stem cells | Allogenic pooled olfactory mucosa-derived mesenchymal stem cells |
| OTHER | Standard treatment according to the Clinical protocols | Standard treatment according to the Clinical protocols |
Timeline
- Start date
- 2020-05-11
- Primary completion
- 2021-06-30
- Completion
- 2021-06-30
- First posted
- 2020-05-11
- Last updated
- 2021-08-23
Locations
1 site across 1 country: Belarus
Source: ClinicalTrials.gov record NCT04382547. Inclusion in this directory is not an endorsement.