Trials / Terminated
TerminatedNCT04335747
COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 53 (actual)
- Sponsor
- Salome Kristensen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The trial is a prospective, observational study aiming to identify risk factors for serious COVID-19 infection by evaluating clinical measures and biomarkers of inflammation in patients with inflammatory rheumatic disease hospitalized with COVID-19 compared with control groups.
Detailed description
The pandemic caused by the coronavirus, SARS-CoV-19, has severely affected health care systems around the world. In Denmark, more than 85,000 patients have a diagnosis of rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus (SLE), or giant cell arthritis, and many are treated with immunosuppressive therapy including biologics. At present it is unclear whether the best course of action during a viral pandemic is to pause treatment with biologics, change to drugs with a different mode of action or continue treatment as usual. Many patients with RA and SLE receive hydroxychloroquine (HCL) treatment for their rheumatic disease, but HCL has also been suggested as a potential treatment for COVID-19 infection. This trial aim to identify risk factors for serious COVID-19 infection by evaluating clinical measures and biomarkers of inflammation, including IL6 and IL10 in patients with inflammatory rheumatic disease hospitalized with COVID-19 compared with measures in control groups.
Conditions
- Rheumatoid Arthritis
- Psoriatic Arthritis
- Axial Spondyloarthritis
- Systemic Lupus Erythematosus
- Giant Cell Arteritis
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | COVID-19 infection | Hospitalisation due to a confirmed COVID-19 infection |
Timeline
- Start date
- 2020-04-23
- Primary completion
- 2021-07-01
- Completion
- 2021-07-01
- First posted
- 2020-04-06
- Last updated
- 2021-07-21
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04335747. Inclusion in this directory is not an endorsement.