NCT04325685

The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia

The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia and Associated Microbiomes.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Northern State Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization. The research team is considering that oropharyngeal decontamination with bacteriophages can prevent the developing of the ventilator - associated pneumoniae. There will be three groups in this investigation: placebo, antiseptic drug (Octenisept) and bacteriophage (Sexthaphag).

Conditions

• Trauma Injury
• Brain Injuries
• Abdominal Sepsis
• Pancreatitis
• Meningitis
• Encephalitis
• Seizures
• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
DRUG	Control	Oropharyngeal decontamination with saline will be performing three time a day every 8 hours during mechanical ventilation
DRUG	Antiseptic Solution	Oropharyngeal decontamination with antiseptic solution will be performing three time a day every 8 hours during mechanical ventilation
DRUG	Bacteriophage	Oropharyngeal decontamination with bacteriophage will be performing three time a day every 8 hours during mechanical ventilation

Timeline

• Start date: 2020-01-01
• Primary completion: 2021-12-31
• Completion: 2023-11-07
• First posted: 2020-03-27
• Last updated: 2023-11-08

Locations

1 site across 1 country: Russia