NCT03845244

Weaning Protocol for High Flow Nasal Cannula Oxygen Therapy

Simultaneous Reduction Versus Flow or Fraction of Inspired Oxygen Reduction First in Patients Ready to Wean From High Flow Nasal Cannula Oxygen Therapy: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

High flow nasal cannula oxygen therapy has been widely used in critically ill patients. Despite effectiveness of high flow nasal cannula as a treatment, optimal methods to withdrawal high flow nasal cannula after recovery from preexisting conditions has not been investigated to date. In this study, we will evaluate the efficacy and safety of three different weaning methods in patients with high flow nasal cannula oxygen therapy.

Detailed description

Comparison of three weaning strategies: flow reduction first versus fraction of inspired oxygen (FiO2) first versus simultaneous reduction

Conditions

• High Flow Nasal Cannula
• Respiratory Insufficiency

Interventions

Type	Name	Description
DEVICE	Flow reduction first	-10L/min q 1hr
DEVICE	FiO2 reduction first	\- 0.1 q 1hr
DEVICE	Simultaneous (flow and FiO2) reduction	-10L/min and -0.1 q 1hr

Timeline

• Start date: 2019-01-24
• Primary completion: 2024-03-31
• Completion: 2024-03-31
• First posted: 2019-02-19
• Last updated: 2024-04-18

Locations

1 site across 1 country: South Korea