NCT03825081

Pilocarpine and Brimonidine in Patients With Monofocal Lenses

Effectiveness of Pilocarpine and Brimonidine to Improve Near Visual Acuity in Patients With Monofocal Intraocular Lenses

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 33 (estimated)
• Sponsor: Massachusetts Eye and Ear Infirmary · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

The current study aims to assess the use of pilocarpine and brimonidine to improve near visual acuity in patietns with monofocal intraocular lenses. Thirty-three subjects with be enrolled and baseline visual acuity with be measured at near and distance. This will be compared to visual acuity after drop administration over 6 hours. A quality of life questionnaire will also be evaluated.

Detailed description

This research study will try to find out if pilocarpine and brimonidine can help people with intraocular lens implants read without reading glasses. Thirty-three subjects will take part in this research study. Baseline visual acuity with be measured at near and distance. This will be compared to visual acuity after drop administration over 6 hours. A quality of life questionnaire will also be evaluated.All subjects will take part at Massachusetts Eye and Ear Infirmary (MEEI).

Conditions

• Presbyopia
• Pseudophakia

Interventions

Type	Name	Description
DRUG	Brimonidine, pilocarpine	1 drop of pilocarpine (0.5%) 1 drop of brimonidine (0.2%)

Timeline

• Start date: 2019-01-21
• Primary completion: 2019-09-01
• Completion: 2019-12-31
• First posted: 2019-01-31
• Last updated: 2019-01-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study