NCT03800277

Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health

Prebiotic Supplementation and Metabolic Endotoxemia and Modulation of the Gut Microbiota: Double-blind and Randomized Parallel Clinical Study of the Efficacy and Synergistical Effect of Cranberry Polyphenols and Inulin From Agaves

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 122 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity and associated metabolic health disorders. The gut microbiota compositions plays a decisive role in glucose metabolism and the chronic inflammatory state associated with insulin resistance. Consuming prebiotic rich diet, including polyphenol and inulin rich food could help modulate favorably the gut microbiota which could lead to a reduction of endotoxemia and beneficial metabolic health effects.

Detailed description

It is now recognized that overweight individuals have altered microbiota which could lead to intestinal barrier defects and chronic inflammation disorders. Polyphenols such as Proanthocyanidins may modulate the gut microbiota thereby providing beneficial effects on metabolic health. Inulin is a well known prebiotic that could stimulate growth of favorable bacteria in the gut. The overall goal is to determine the efficacy and synergy of a supplement of polyphenols from cranberry extract with or without a supplement of inulin from agaves to reduce chronic inflammation and endotoxemia and to improve glucose metabolism and insulin sensitivity by modulating microbiota of overweight human subjects with metabolic syndrome symptoms.

Conditions

• Endotoxemia
• Metabolic Syndrome
• Glucose Metabolism Disorders
• Insulin Resistance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Cranberry	Supplementation of polyphenols from cranberry extract
DIETARY_SUPPLEMENT	Agaves	Supplementation of inulin from Agaves powder
DIETARY_SUPPLEMENT	Placebo	Supplementation with placebo

Timeline

• Start date: 2018-11-05
• Primary completion: 2020-12-31
• Completion: 2021-12-31
• First posted: 2019-01-11
• Last updated: 2023-03-21

Locations

1 site across 1 country: Canada