NCT03793244

TARGET-Metabolic Effects

The Augmented Versus Routine Approach to Giving Energy Trial Metabolic Effects Sub-study (TARGET-ME)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 42 (actual)
• Sponsor: Australian and New Zealand Intensive Care Research Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The estimation of calorie needs during routine practice in critically ill patients is highly variable and the thermogenic effect of continuous delivery of enteral nutrition (EN) on overall calorie utilisation in critically ill adults is unknown. The TARGET-ME study is a substudy of the TARGET trial (NCT02306746). The TARGET trial provides the perfect opportunity to measure calorie utilisation via indirect calorimetry (IC) and ventilator-derived carbon dioxide production (VCO2) to compare measured calorie utilisation to estimation methods, determine the potential thermic effect of EN solutions with different energy concentrations and investigate any associations with outcome.

Conditions

• Critical Illness
• Enteral Nutrition

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	TARGET protocol EN 1.5 kcal/mL	Enteral nutrition

Timeline

• Start date: 2017-07-01
• Primary completion: 2018-07-10
• Completion: 2018-08-01
• First posted: 2019-01-04
• Last updated: 2019-01-04

Locations

1 site across 1 country: Australia