NCT03766971

Influence of Tobacco Use on Cannabis Use

• Status: Suspended
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.

Conditions

• Cannabis Use
• Tobacco Use

Interventions

Type	Name	Description
BEHAVIORAL	7 days of Tobacco Cessation	Participants will be randomly assigned to 7 days of tobacco cessation.
BEHAVIORAL	21 days of Tobacco Cessation	Participants will be randomly assigned to 21 days of tobacco cessation.
DRUG	Cannabis	Participants will receive cannabis.

Timeline

• Start date: 2020-02-01
• Primary completion: 2026-11-30
• Completion: 2027-11-30
• First posted: 2018-12-06
• Last updated: 2025-08-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study