NCT03685942

Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder

Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder(LUMIDEP)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Centre Psychothérapique de Nancy · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the addition of light therapy with LUMINETTE device to usual treatment (antidepressant drug and psychotherapy) in the treatment of Major Depressive Disorder (MDD). Half of the participants will receive active light therapy with LUMINETTE device while the other half will receive placebo light therapy with LUMINETTE placebo device.

Detailed description

Major depressive disorder (MDD) is a world wide spread disorder. According to the World health organization, MDD affects more than 300 million people of all ages in the world. Treatments of MDD include pharmacological treatment and psychotherapy. Pharmacological treatments, mostly serotonin selective reuptake inhibitors, have a delayed onset of action, require long-term treatment and have partial efficacy. In fact, only one third of patients respond to the first antidepressant treatment and two-third after multiple trials. So, there is a need for new treatment strategy. Light therapy is a well established non pharmacological treatment of seasonal affective disorder, a clinical subtype of affective disorder characterized by recurrent episodes of depression occurring with a seasonal pattern. Patients are exposed to artificial light for a variable duration and intensity. Although the precise mechanism of bright light therapy remains unknown, it is thought to act through the eyes by activating the suprachiasmatic nucleus, the principal circadian pacemaker.

Conditions

• Major Depressive Disorder
• Unipolar Depression

Interventions

Type	Name	Description
DEVICE	active light therapy (LUMINETTE®)	light therapy on a portable light visor device
DEVICE	placebo light therapy	placebo portable light visor device

Timeline

• Start date: 2019-01-16
• Primary completion: 2023-09-08
• Completion: 2023-09-08
• First posted: 2018-09-26
• Last updated: 2024-08-21

Locations

1 site across 1 country: France