| Recruiting | Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lun NCT07216404 | Alan Davis | Phase 2 |
| Recruiting | RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) NCT07266545 | Mayo Clinic | Phase 4 |
| Enrolling By Invitation | Bright Light Therapy for Depressed Geriatric Inpatients NCT07002554 | Medical University of South Carolina | Phase 2 |
| Recruiting | Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depre NCT06860165 | Emobot | — |
| Recruiting | Transcranial Direct Current Stimulation for Depression NCT07042217 | Soterix Medical | N/A |
| Withdrawn | Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST) NCT03895658 | National Institute of Mental Health (NIMH) | Phase 1 |
| Completed | Mood Disorders in Multiple Sclerosis Patients NCT06652308 | Islamic Azad University, Sanandaj | — |
| Recruiting | Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression NCT06363981 | Jakub Antczak | N/A |
| Recruiting | Cognitive Enhancement in Unipolar Depression With Yoga NCT06472492 | University of Pittsburgh | N/A |
| Recruiting | Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Dep NCT06371352 | Jakub Antczak | N/A |
| Recruiting | How to Reduce Suicidal Thoughts and Impulsivity in Depression NCT05894980 | Centre Hospitalier Universitaire de Besancon | N/A |
| Recruiting | Enoxolone in Major Depression - Biomarker-outcome Relationship NCT05570110 | Philipps University Marburg | Phase 1 / Phase 2 |
| Completed | TBS Treatment for Treatment-Resistant Depression NCT05388539 | University of Sao Paulo | N/A |
| Recruiting | Effect of Tao Calligraphy Meditation and Energized Water on Depression NCT06934330 | Sha Research Foundation | N/A |
| Completed | RTMS Feasibility Study on Adolescent Depression Stimulation NCT06126198 | Uppsala University | N/A |
| Completed | Ketamine As an Adjunctive Therapy for Major Depression (2) NCT04939649 | University of Dublin, Trinity College | Phase 3 |
| Terminated | Efficacy of Daylight as Adjunctive Treatment in Patients With Depression NCT04712968 | University of Aarhus | N/A |
| Completed | Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study NCT04889976 | University of Sao Paulo | N/A |
| Completed | Home-administered tDCS for Treatment of Depression NCT04781127 | Soterix Medical | Phase 1 |
| Completed | Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression NCT04701866 | Douglas Mental Health University Institute | N/A |
| Unknown | Assesment of Retinal Nerve Fiber Layer in First Episode Depressive Patients Using Selective Serotonin Reuptake NCT04717921 | Mehmet Diyaddin Güleken | — |
| Unknown | Development of a Software Tool, Using Artificial Intelligence, That Integrates Clinical, Biological, Genetic a NCT05801562 | IRCCS San Raffaele | — |
| Unknown | Sensor-based Characterization of Depression NCT04370002 | Massachusetts General Hospital | — |
| Completed | Voice Changes During ECT NCT04420793 | Medical University of South Carolina | — |
| Completed | Mechanism of Action of Electroconvulsive Therapy NCT04059952 | Massachusetts General Hospital | — |
| Completed | Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder NCT03685942 | Centre Psychothérapique de Nancy | N/A |
| Completed | Efficacy of Convulsive Therapies During Continuation NCT03711019 | Centre for Addiction and Mental Health | N/A |
| Completed | Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression NCT03191058 | University of Texas Southwestern Medical Center | N/A |
| Completed | Evaluation of Metacognitive Training for Depression (D-MCT) in Outpatient Care NCT03268434 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Ketamine as an Adjunctive Therapy for Major Depression NCT03256162 | St Patrick's Hospital, Ireland | Phase 1 |
| Unknown | Effects of Mindfulness Based Cognitive Therapy on Emotional Processing NCT03358056 | Parc de Salut Mar | N/A |
| Completed | Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders NCT03315897 | Lars Vedel Kessing | Phase 2 |
| Completed | Effects of Erythropoietin for Cognitive Side-effects of ECT NCT03339596 | Martin Balslev Jørgensen | Phase 2 |
| Completed | The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic NCT03156504 | Mayo Clinic | Phase 4 |
| Completed | Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Usi NCT03033420 | Psychiatric Centre Rigshospitalet | N/A |
| Completed | ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) NCT03113968 | Bo Hu | Phase 2 / Phase 3 |
| Unknown | Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode NCT03227133 | Centre Hospitalier Universitaire de Besancon | N/A |
| Completed | Long-term Efficacy of Metacognitive Training for Depression (D-MCT) NCT02771535 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Terminated | Response to Social Rejection in Suicidal Behavior NCT02710279 | University Hospital, Montpellier | N/A |
| Completed | Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression NCT02530164 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Improve: Integrating Emotion Focused Components Into Psychological Therapy NCT02822443 | University of Bern | Phase 2 |
| Completed | A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise NCT02407704 | Kirk Erickson, PhD | Phase 4 |
| Completed | Ketamine Trial for the Treatment of Depression NCT02401139 | The University of New South Wales | Phase 1 |
| Completed | Thinking Healthy Program - Peer Delivered (Pakistan) NCT02111915 | University of Liverpool | N/A |
| Completed | Thinking Healthy Program - Peer Delivered, India (THPP-I) NCT02104232 | London School of Hygiene and Tropical Medicine | N/A |
| Completed | Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression NCT02750631 | New York State Psychiatric Institute | N/A |
| Unknown | Effects of Repeated Attachment Security Priming on Depressed Mood: a Clinical Study NCT01694030 | University of Southampton | Phase 1 |
| Completed | Depression Outcomes Study of Exercise NCT00964054 | National Institute of Mental Health (NIMH) | Phase 1 |
| Completed | tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients NCT01644747 | Centre Hospitalier Universitaire de Besancon | Phase 2 |
| Unknown | Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression NCT01574742 | Shalvata Mental Health Center | Phase 1 |
| Completed | Investigating tDCS as a Treatment for Unipolar and Bipolar Depression NCT01562184 | The University of New South Wales | Phase 2 / Phase 3 |
| Completed | Neurofeedback as a Treatment Tool for Depression NCT01544205 | Cardiff University | N/A |
| Completed | PET and MRI Brain Imaging of Bipolar Disorder NCT01880957 | Stony Brook University | N/A |
| Completed | A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior NCT01447602 | New York State Psychiatric Institute | Phase 3 |
| Completed | Validation of the Spanish Version of the Clinically Useful Depression Outcome Scale (CUDOS) Scale NCT01360307 | AstraZeneca | — |
| Unknown | MBCGT and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient NCT01894932 | National Taiwan University Hospital | N/A |
| Withdrawn | Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder NCT01313403 | National Institute of Mental Health (NIMH) | N/A |
| Terminated | EScitalopram PIndolol ONset of Action NCT01219686 | Markus KOSEL | Phase 2 / Phase 3 |
| Completed | Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression NCT01881763 | Northwell Health | Phase 4 |
| Suspended | Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments NCT01557192 | Mclean Hospital | Phase 1 |
| Completed | PET Whole Body Distribution Studies Using [11C]CUMI NCT01132872 | National Institute of Mental Health (NIMH) | — |
| Unknown | Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression NCT01012856 | University of Zurich | Phase 2 |
| Completed | Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding NCT00922064 | Medical University of Vienna | Phase 4 |
| Completed | Berlin Magnetic Seizure Therapy Depression Trial 01 NCT00914680 | Charite University, Berlin, Germany | Phase 3 |
| Completed | Repetitive Transcranial Magnetic Stimulation and Venlafaxine in Depression NCT00714090 | Club rTMS et Psychiatrie | Phase 3 |
| Terminated | Deep Brain Stimulation for Major Depressive Disorder NCT00617162 | Abbott Medical Devices | N/A |
| Completed | The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression NCT00517387 | University of British Columbia | Phase 3 |
| Terminated | The Antidepressant Efficacy of the Anticholinergic Scopolamine NCT00369915 | National Institute of Mental Health (NIMH) | Phase 2 |
| Completed | The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression NCT00125957 | Mclean Hospital | Phase 3 |
| Completed | Natural Supplements for Unipolar Depression NCT00226356 | Cambridge Health Alliance | Phase 4 |
| Completed | Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression NCT00179244 | Vanderbilt University | Phase 3 |
| Completed | Lamotrigine Augmentation in Resistant Depression NCT00901407 | Louisiana State University Health Sciences Center in New Orleans | N/A |
| Terminated | Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies NCT00055575 | National Institute of Mental Health (NIMH) | Phase 2 |
| Completed | Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression. NCT00158990 | Hadassah Medical Organization | Phase 3 |
| Completed | RCT of Psychoeducational Program of Depression NCT00319540 | Norwegian Institute of Public Health | Phase 2 |
| Completed | Transcranial Magnetic Treatment (TMS) in Unipolar Depression NCT00186784 | St. Joseph's Healthcare Hamilton | EARLY_Phase 1 |
| Completed | Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group NCT00265291 | National Institute of General Medical Sciences (NIGMS) | Phase 2 |
| Completed | Paroxetine and Interpersonal Psychotherapy for Maintaining Health and Well-being in Elderly Individuals With D NCT00178100 | University of Pittsburgh | Phase 4 |
| Completed | The Effects of Sleep Deprivation on Antidepressant Response NCT00178074 | University of Pittsburgh | Phase 4 |
| Completed | Amitriptyline and Paroxetine Treatment of Major Depression NCT01049347 | Central Institute of Mental Health, Mannheim | Phase 3 |
| Completed | Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders NCT00001545 | National Institute of Mental Health (NIMH) | Phase 2 |