NCT03641768

Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Conditions

• Alzheimer Dementia
• Posttraumatic Stress Disorder
• Traumatic Brain Injury

Interventions

Type	Name	Description
DEVICE	MRI	You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.
DEVICE	PET	You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.
DEVICE	18F-Florbetapir	At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.
DEVICE	Radioligand 18F-AV-1451	At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.

Timeline

• Start date: 2019-01-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2018-08-22
• Last updated: 2018-10-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study