NCT03512392

Role of Active Deresuscitation After Resuscitation-2

Role of Active Deresuscitation After Resuscitation- 2: a Pilot Randomised Controlled Trial of Conservative Fluid Management Versus Usual Care in Critical Illness

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (actual)
• Sponsor: Belfast Health and Social Care Trust · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

RADAR-2 will be a randomised, open-label, allocation concealed, pilot trial of conservative fluid administration and deresuscitation compared with usual care in patients who are critically ill.

Detailed description

The optimal approach to fluid balance in critically ill patients is uncertain. A recent systematic review found low quality evidence in favour of a conservative fluid or deresuscitative approach (active removal of accumulated fluid using diuretics and/or renal replacement therapy) compared with a liberal strategy or usual care. The RADAR-2 pilot randomised trial will compare conservative fluid and deresuscitation with usual care in patients who are mechanically ventilated in an intensive care unit. The main hypothesis is that in critically ill patients, a post-resuscitation fluid strategy comprising conservative fluid administration and active deresuscitation reduces net fluid balance, is safe and improves clinical outcomes.

Conditions

• Critical Illness
• Sepsis
• Trauma

Interventions

Type	Name	Description
OTHER	Conservative fluid and deresuscitation strategy	Conservative administration of intravenous fluid and active deresuscitation using diuretics or renal replacement therapy for eligible patients
OTHER	Usual care strategy	Usual care at the discretion of the clinical team

Timeline

• Start date: 2018-04-10
• Primary completion: 2020-01-21
• Completion: 2021-07-17
• First posted: 2018-04-30
• Last updated: 2022-04-21

Locations

8 sites across 1 country: United Kingdom