NCT03383068

Research of Intensive Metabolic Intervention Before Pregnancy in PCOS

Research of Intensive Metabolic Intervention Before Pregnancy in Polycystic Ovary Syndrome

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.

Detailed description

To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women with IGR / DM not effective of metformin treatment at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.

Conditions

• PCOS
• Impaired Glucose Tolerance

Interventions

Type	Name	Description
DRUG	Acarbose 100 MG	for metformin uneffective subjects, using acarbose for 3 months
DRUG	Exenatide	for metformin uneffective subjects, using Exenatide for 3 months
DRUG	Orlistat	for metformin uneffective subjects, using Orlistatfor 3 months
DRUG	Metformin	metformin effective subjects,act as control group

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-12-31
• Completion: 2020-06-30
• First posted: 2017-12-26
• Last updated: 2017-12-26

Locations

1 site across 1 country: China