NCT03271151

Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty

Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty: A Double-blinded Randomized Control Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 25 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Post-discharge pain after total knee arthroplasty remains problematic; many patients have excessive pain at the 2 week time point (and often thereafter). Reduction in opioid use has become a national goal, due to the 'epidemic' in opioid misuse. In addition to enrolling non-opioid users, we will enroll up to 15 chronic opioid users.

Conditions

• Joint Disease
• Pain, Acute
• Pain, Chronic

Interventions

Type	Name	Description
DRUG	Cymbalta	Duloxetine ("Cymbalta") is a serotonin and norepinephrine dual reuptake inhibitor (SNRI) that is an effective treatment for painful diabetic neuropathy. It is approved for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain
OTHER	Placebo	Placebo to compare outcomes against Duloxetine

Timeline

• Start date: 2017-09-28
• Primary completion: 2020-12-03
• Completion: 2021-02-19
• First posted: 2017-09-01
• Last updated: 2024-12-27
• Results posted: 2022-04-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study