NCT03255408

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Calgary · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

Detailed description

The investigators will explore the relationship between changes in Cerebral Blood Flow (CBF) and ventilatory chemoreflexes i.e. Acute Ventilatory Response to Hypoxia (AHVR) and Acute Hypercapnic Ventilatory Response (HCVR) before, during and after sleep under normoxic conditions and sleep accompanied by isocapnic Intermittent Hypoxia (IH) among healthy human study participants. A pharmacological intervention will be utilized to manipulate the CBF in a randomized order. The study participants will also be randomly assigned the order to sleep either under normoxia or IH exposure. The experiments will be separated from one another with an interval of sufficient drug and IH exposure washout period. The venous blood samples and urinary samples will be collected for the vascular biomarkers.

Conditions

• Obstructive Sleep Apnea of Adult
• Hypoxia, Brain
• Sleep Apnea
• Sleep Disorder
• Stroke
• Blood Pressure
• Endothelial Dysfunction
• Oxidative Stress

Interventions

Type	Name	Description
DRUG	Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep	The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure
DRUG	Drug Lowering CBF and Intermittent Hypoxia Sleep	The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure
DRUG	Placebo and Normoxia Sleep	The study participants will take Placebo and sleep under Normoxia Exposure
DRUG	Placebo and Intermittent Hypoxia Sleep	The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-12-30
• Completion: 2024-12-30
• First posted: 2017-08-21
• Last updated: 2022-11-04