NCT03172130

Sham CPAP vs. Straight CPAP for Chronic Cough

Prospective Study of Efficacy of Sham CPAP vs. Straight CPAP on Cough Intensity in Patients With Chronic Cough

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Krishna M. Sundar · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Chronic cough is an important clinical problem in primary care and sub-specialty practice. Besides the distress experienced by patients with chronic cough, significant healthcare resources are expended to understand the role of gastroesophageal reflux, asthma and post-nasal drip in understanding their contribution to cough. Obstructive sleep apnea (OSA) is common in patients with chronic cough. More importantly, treatment of OSA with continuous positive airway pressure (CPAP) has led to improvement in cough for chronic cough patients. Mechanisms by which OSA therapy with CPAP can improve cough includes beneficial effects on reflux and airway inflammation. The aim of this study is to definitively establish that CPAP therapy for treatment of OSA in chronic cough patients improves cough. While these patients with chronic cough are not routinely screened and treated for OSA, this study aims to evaluate these chronic cough patients with screening questionnaires for OSA and if necessary with polysomnography and randomize them to either CPAP or sham CPAP for 6 weeks.

Conditions

• Chronic Cough
• OSA

Interventions

Type	Name	Description
DEVICE	Straight CPAP
DEVICE	Sham CPAP

Timeline

• Start date: 2014-10-13
• Primary completion: 2019-11-25
• Completion: 2019-11-25
• First posted: 2017-06-01
• Last updated: 2020-06-18
• Results posted: 2020-06-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study