Trials / Completed
CompletedNCT02914756
HMGB1 in ICU-survivors
Cognitive Impairment After Critical Illness, Links Between Sepsis, Cognitive Function and Non-resolving Inflammation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (actual)
- Sponsor
- Karolinska University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?
Conditions
Timeline
- Start date
- 2014-05-01
- Primary completion
- 2018-09-01
- Completion
- 2018-09-01
- First posted
- 2016-09-26
- Last updated
- 2019-04-12
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT02914756. Inclusion in this directory is not an endorsement.