NCT02903251

Oxytocin and Alcohol Withdrawal and Dependence

Acute and Long-term Effects of Intranasal Oxytocin in Alcohol Withdrawal and Dependence: A Prospective Randomized Parallel Group Placebo-controlled Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of oxytocin nasal spray on alcohol withdrawal and dependence in adults admitted for detoxification of alcohol, and during the following 4 weeks in an outpatient setting. Half of the participants will receive oxytocin nasal spray, the other half placebo nasal spray.

Conditions

• Alcoholism
• Substance-Related Disorders

Interventions

Type	Name	Description
DRUG	intranasal oxytocin spray	6 insufflations (24 IU of oxytocin total) given twice daily, day 1-3. 2 insufflations (8 IU of oxytocin total) as needed, max thrice daily, day 3-30.
OTHER	intranasal spray without oxytocin	6 insufflations (24 IU of placebo total) given twice daily, day 1-3. 2 insufflations (8 IU of placebo total) as needed, max thrice daily, day 3-30.

Timeline

• Start date: 2016-10-01
• Primary completion: 2018-01-22
• Completion: 2018-01-22
• First posted: 2016-09-16
• Last updated: 2019-02-26

Locations

1 site across 1 country: Norway