NCT02814994

Respiratory System Compliance Guided VT in Moderate to Severe ARDS Patients

Respiratory System Compliance Guided Tidal Volume in Moderate to Severe ARDS Patients: A Multicenter Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 242 (actual)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The Acute Respiratory Distress Syndrome (ARDS) is one of common clinical critically diseases. In the United States, the incidence of ARDS reaches 31%, which is one of the main causes of death in patients. There is no unified treatment process for ARDS currently and the treatment measures are not yet standardized, so the standardization of ARDS treatment processes is needed to reduce mortality in patients. Following the evidence-based medicine principles and six-step treatment standards of ARDS, this study uses the method of multi-center randomized controlled clinical trials to evaluate the standardized treatment process of ARDS, which provides the basis for the standardized treatment of ARDS.

Detailed description

From September 1st 2012 to September 30th 2014, all ARDS patients admitted to the ICUs will be enrolled. The demographic characteristics, diagnosis, formerly medical history, Ventilator indications, Ventilator data, other respiratory treatments, weaning outcome and 28 day mortality will be recorded.

Conditions

• Respiratory Failure
• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	tidal volume guided by respiratory system compliance	ventilated with tidal volume guided by respiratory system compliance
BEHAVIORAL	low tidal volume	ventilation ventilated with low tidal volume

Timeline

• Start date: 2012-09-01
• Primary completion: 2014-05-01
• Completion: 2014-06-01
• First posted: 2016-06-28
• Last updated: 2016-06-28

Locations

1 site across 1 country: China