NCT02739971

Dietary Reduction of AGEs to Prevent Cognitive Decline in Elderly Diabetics

Dietary Reduction of Advanced Glycation End Products to Prevent Cognitive Decline in Elderly Diabetics - a Randomized Pilot Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Basic science and observational human studies suggest that high conentrations of circulating Advanced Glycation End-products (AGEs) may promote cognitive decline in older adults. The purpose of this pilot study is to test the methodology and feasibility of a dietary intervention to lower AGEs in elderly diabetics in order to lay the foundations for a future fully powered randomized clinical trial (RCT).To this end, the present study is focused on recruitment strategies, adherence to an innovative intervention in older adults and study methods. An exploratory aim will be the effect of the intervention on cognition and cerebral blood flow in order to obtain necessary data to estimate effect-size for a future fully-powered RCT.

Conditions

• Cognitive Decline
• Aging
• Type 2 Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Low AGEs diet	Oral and written instructions on how to reduce AGEs in diet, mainly by changing cooking methods in addition to standard of care dietary guidance for type 2 diabetes
BEHAVIORAL	Standard of care dietary guidance for Type 2 diabetes	Oral and written instructions for standard of care dietary guidance for type 2 diabetes

Timeline

• Start date: 2016-06-01
• Primary completion: 2019-06-01
• Completion: 2020-06-01
• First posted: 2016-04-15
• Last updated: 2021-03-23

Locations

1 site across 1 country: Israel