NCT02661269

Relation Between the Increase of Peripheral Edema by Fluid Therapy and the Decrease in Microcirculatory Vesseldensity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 110 (actual)
• Sponsor: Frisius Medisch Centrum · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Can videomicroscopy of the sublingual microcirculation detect the increase in edema before peripheral edema will appear? By measuring the decrease in vesseldensity after strong positive fluid balances within septic patients versus euvolemic post-cardiac surgery patients. Measuring reactance and resistance (BIVA method) to determine volume status. Primary outcome: \- Total vessel density (TVD) Secondary outcome: * Fluid balance * BIVA measurements (reactance \& resistance)

Detailed description

There are a lot of methods to determine if a patient is fluid-responsive, however a moment to stop fluid therapy is lacking. So the purpose of this study is to find a 'stop' moment for fluid therapy before peripheral edema will be present. With sublingual measurements of the vessel density with the Cytocam-IDF, comparing the septic patients with fluid overload , euvolemic post-cardiac surgery patients at the arrival on the ICU and healthy volunteers we can determine if there is a decrease in vessel density during fluid loading. To give a accurate view on fluid overload we include a bio-impedance measurement of reactance and resistance. Fluid balances are recorded very accurate by our electronic patient record.

Conditions

• Edema
• Sepsis

Interventions

Type	Name	Description
DEVICE	Videomicroscopy of the sublingual microcirculation	Measuring total vessel density with the Cytocam-IDF camera.
DEVICE	Bio-impedance measurements.	measuring resistance and reactance with the BIVA method.

Timeline

• Start date: 2015-11-01
• Primary completion: 2018-02-15
• Completion: 2018-02-15
• First posted: 2016-01-22
• Last updated: 2018-03-27

Locations

1 site across 1 country: Netherlands