NCT02653703

L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain

High-concentration L-menthol as a Counter-irritant to TRPA1-induced Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: —
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in healthy human volunteers.

Detailed description

This study is designed as an experimental model in healthy humans.

Conditions

• Inflammation
• Pruritus
• Hyperalgesia

Interventions

Type	Name	Description
OTHER	Topical L-menthol 40%	Naturally occurring local anaesthetic, counterirritant and TPRM8-agonist. CAS Number: 2216-51-5
OTHER	Vehicle, topical ethanol 96%	Organic solvent CAS Number: 64-17-5

Timeline

• Start date: 2014-10-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2016-01-12
• Last updated: 2016-01-12