NCT02611271

Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy

Elimination of Antibiotics During Combined Continuous Renal Replacement Therapy and Cytosorb Adsorptive Therapy in Patients With Sepsis and Acute Kidney Injury

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate \- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

Detailed description

Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial.

Conditions

• Critical Illness
• Sepsis
• Acute Kidney Injury

Interventions

Type	Name	Description
OTHER	Monitoring of antibiotic drug removal	No study specific intervention will be performed

Timeline

• Start date: 2017-12-01
• Primary completion: 2020-08-31
• Completion: 2020-12-31
• First posted: 2015-11-20
• Last updated: 2020-05-07

Locations

1 site across 1 country: Germany