NCT02359266

Vitamin D Improves Depression in Liver Patients

Clinical Trial Investigating the Role of Vitamin D in the Treatment of Depression in Patients With Chronic Liver Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 111 (actual)
• Sponsor: Universität des Saarlandes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the efficacy of vitamin D replacement therapy in reducing depressive symptoms in patients with chronic liver disease and vitamin D deficiency. Patients with normal vitamin D levels will be monitored as controls, and they will not receive any intervention.

Detailed description

Patients with chronic liver diseases regularly suffer from vitamin D deficiency and depression. A recent meta-analysis reported an inverse correlation between depression and vitamin D levels. Indeed, vitamin D receptor is present and genomic and nongenomic vitamin D receptor-mediated signalling has been described in brain. This intervention study investigates whether vitamin D therapy ameliorates depressive symptoms in chronic liver disease patients. The investigators hypothesise that depressive symptoms will improve upon vitamin D replacement therapy.

Conditions

• Depression
• Chronic Liver Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D	Given to patients with existing vitamin D deficiency

Timeline

• Start date: 2011-12-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2015-02-09
• Last updated: 2015-02-09

Locations

1 site across 1 country: Germany