NCT02306551

Well Being And Resilience: Mechanisms of Transmission of Health and Risk

Well Being And Resilience: Mechanisms of Transmission of Health and Risk in Parents With Complex Mental Health Problems and Their Offspring

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 93 (actual)
• Sponsor: Susanne Harder · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to establish a cohort of pregnant women with severe mental disorder and to identify biological and psycho-social transmission mechanisms involved in the development of 'risk' and 'resilience' in the offspring. It is assumed that both 'resilient' and 'risk' development in offspring are caused by a complex interaction between multiple biological, psychological and social factors. The project focuses specifically on exploring the impact of physiological stress-sensitivity, attachment, care-giving and the familial and social context for care-giving. Previous studies support these factors as important for the development of these infants, but systematic research using a prospective design is needed to strengthen evidence and elucidate the importance of these factors in more detail. The interaction over time of physiological stress-sensitivity, attachment, care-giving and the familial and social context for care-giving are evaluated in terms of the evolution of very early indicators of developmental risk and resilience in infants with a known highly increased risk for developing a mental disorder.The findings of the study may potentially lead to more specific targets for preventive interventions, which can improve developmental outcome for these infants.

Conditions

• Psychotic Disorder
• Bipolar Disorder
• Depressive Disorder

Interventions

Type	Name	Description
OTHER	Biological and psycho-social risk and resilience factors	Naturalistic study, no active intervention or exposure is administered

Timeline

• Start date: 2014-09-01
• Primary completion: 2020-08-01
• Completion: 2021-09-01
• First posted: 2014-12-03
• Last updated: 2023-01-25

Locations

3 sites across 2 countries: Denmark, United Kingdom