NCT02273063

rTMS for PTSD Comorbid With Major Depressive Disorder

5Hz Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder Comorbid With Major Depressive Disorder

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Butler Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.

Detailed description

This study aims to evaluate the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for adults with comorbid posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Although standard rTMS uses stimulations delivered to the left prefrontal cortex at 10 pulses per second, prior work has shown that other stimulation frequencies may work for both PTSD and MDD. In this study, we examine the efficacy of left-sided 5Hz in patients with PTSD and MDD, hypothesizing that this lower frequency will improve PTSD and MDD symptoms.

Conditions

• Posttraumatic Stress Disorder
• Major Depressive Disorder
• Transcranial Magnetic Stimulation, Repetitive

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation (TMS)	Up to 40 sessions of TMS delivered with the first 35 sessions delivered over 7 weeks, and final 5 treatments delivered in taper schedule over 3 weeks. Treatment is adjunct to ongoing stable pharmacotherapy.

Timeline

• Start date: 2014-10-01
• Primary completion: 2016-04-22
• Completion: 2016-04-22
• First posted: 2014-10-23
• Last updated: 2018-10-04
• Results posted: 2018-10-04

Locations

2 sites across 1 country: United States