NCT02236416

Physical Exercise for Prevention of Dementia

Physical Exercise and Prevention of Cognitive Decline in Subjects at Risk of Dementia: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (actual)
• Sponsor: University of Molise · Academic / Other
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults

Detailed description

Community-dwelling volunteers, recruited from social centers, were invited to an in-person assessment that included a medical history questionnaire and examination, anthropometric measurements, blood tests for cardiovascular risk, and several outcome measures. Participants meeting the inclusion criteria were divided in 3 groups (participants without subjective or objective cognitive impairment, with subjective memory complaints and with mild cognitive impairments) and randomly assigned (1:1) to an experimental group or a control group, using a list of random numbers generated by a statistical software. The list was kept in a sealed envelope and a researcher, not directly involved in the recruitment and in the evaluation of the participants, assigned the allocation numbers.

Conditions

• Memory Disorders
• Mild Cognitive Impairment
• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Intervention group	Supervised, multimodal physical activity including aerobic, resistance and stretching exercises
BEHAVIORAL	Control group	Usual physical activity, generally consisting in long walks and/or stretching, toning and/or balance exercises, or posture education

Timeline

• Start date: 2011-05-01
• Primary completion: 2020-07-01
• Completion: 2020-07-01
• First posted: 2014-09-10
• Last updated: 2021-07-21

Locations

1 site across 1 country: Italy