NCT02200185

Titrated Versus High and Low Dose Nebulized Morphine to Reduce Pain in Emergency Settings

Efficacy and Safety of Nebulized Morphine Given at Two Different Doses Compared to Intravenous Morphine in Post-traumatic Acute Pain: a Randomized Controlled Double Blind Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: University of Monastir · Academic / Other
• Sex: All
• Age: 8 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The investigators test a different technique using morphine to improve pain relief in patient visiting the emergency department with acute trauma pain, for this we are comparing three different methods of morphine administration: * intravenous titrated morphine * low dose nebulized morphine and * high dose nebulized morphine

Detailed description

Trauma patients are frequent in emergency department settings, and often require urgent care. taking care of this patients consists on taking care of their pain and then the specific treatment of their traumatic lesions. actually, the most used medicine and most efficient one in treating pain is morphine, it's mechanism of action is by acting on receptors located on neuronal cell membranes and inhibit neurotransmitter release. The most applied administration root of morphine is by intravenous (IV) titration or IV continuous perfusion, but until now, there is no clear recommendation concerning the superiority of this root over other administration techniques such as nebulization. In this study we aimed to investigate the efficiency, the feasibility and the tolerance of three morphine administration roots in patients with acute traumatic pain and to clarify the most adequate one to apply in emergency department settings.

Conditions

• Post-Traumatic Headache
• Acute Pain

Interventions

Type	Name	Description
DRUG	IV titrated morphine	Intravenous morphine : 2 mg every 5 minutes by IV root and nebulized placebo: * SS nebulised : 5 ml SS nebulised over 10 minutes and repeated 3 times
DRUG	Low dose nebulised morphine	10 mg morphine in 4 ml Serum Saline(SS) nebulised over 10 minutes and repeated 3 times, and SS IV placebo : 2 ml by IV root every 5 minutes
DRUG	High dose nebulised morphine	20 mg morphine in 3 ml serum saline (SS) nebulised over 10 minutes and repeated 3 times, and SS IV placebo : 2 ml by IV root every 5 minutes

Timeline

• Start date: 2012-04-01
• Primary completion: 2014-07-01
• Completion: 2014-07-01
• First posted: 2014-07-25
• Last updated: 2014-12-02

Locations

1 site across 1 country: Tunisia