NCT02179749

Mifepristone Treatment of Alcohol Use Disorder

Glucocorticoid Antagonist Treatment of Alcohol Use Disorder

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 103 (actual)
• Sponsor: The Scripps Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up visit at Week 12.

Conditions

• Alcohol Dependence
• Alcohol Use Disorders
• Alcohol Abuse
• Alcoholism

Interventions

Type	Name	Description
DRUG	Mifepristone 1200 mg daily	Mifepristone, 300 mg tablets, Four tablets daily/am for 1-week duration.
BEHAVIORAL	Standardized behavioral therapy	Standardized behavioral therapy 1 time per week for 8 week duration.
DRUG	Placebo	Placebo tablets, Four tablets daily/am for 1-week duration.

Timeline

• Start date: 2014-09-01
• Primary completion: 2019-11-01
• Completion: 2019-11-06
• First posted: 2014-07-02
• Last updated: 2022-10-06
• Results posted: 2022-10-06

Locations

1 site across 1 country: United States