NCT02139488

Organ Motion and Early Tumor Response Measurement

Organ Motion and Early Tumor Response Measurement During Chemotherapy for Esophageal Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: The Netherlands Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To quantify motion based variation of the target volume of the primary tumor over the course of chemoradiotherapy in esophageal cancer patients, and to use this information to calculate appropriate PTV (planning target volume) margins according to the margins recipe for patients receiving trimodality (neoadjuvant chemoradiation and surgery) or definitive chemoradiation in order to personalize radiation treatment, resulting in either better target coverage or a reduction in normal tissue radiation exposure.

Detailed description

A single center prospective observational study will be performed in esophageal cancer patients. This study registers motion of the esophageal tumor, using 4D planning CT scans and repeated 4D CBCT scanning. Motion of fiducial markers inserted into the esophageal wall, will be used as a surrogate for tumor motion in the limited image quality of CBCT scans. Patients planned for trimodality treatment will additionally be imaged by serial 4D Pet CT and MRI in week 0 (before start chemoradiotherapy), week 3 (during chemoradiotherapy) and week 10 (just prior to surgery) to observe (early) signs of tumor response. Patients planned for definitive chemoradiation will not receive extra MRI imaging during treatment because of the inability to correlate this imaging with pathological response.

Conditions

• Esophageal Cancer
• Chemoradiation

Interventions

Type	Name	Description
OTHER	Fiducial markers
OTHER	Fiducial markers, Pet and MRI	Insertion of Fiducial markers in esophageal wall.

Timeline

• Start date: 2014-04-18
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2014-05-15
• Last updated: 2019-06-27

Locations

1 site across 1 country: Netherlands