NCT02102113

Probing the Cannabinoid System in Individuals With a Family History of Psychosis

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 21 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system. This will be tested by studying individuals with and without a family history of psychosis and comparing their responses to delta 9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that compared to controls with no family history of psychoses, individuals with a family history of psychoses will have an altered response to THC.

Conditions

• Psychosis
• Cannabis Use
• THC
• Marijuana
• Schizophrenia

Interventions

Type	Name	Description
DRUG	Placebo	placebo
DRUG	Very Low Dose THC	Subjects will receive 0.010mg/kg.
DRUG	Low Dose THC	Subjects will receive 0.018 mg/kg over 20 minutes.

Timeline

• Start date: 2014-01-01
• Primary completion: 2026-06-01
• Completion: 2026-12-01
• First posted: 2014-04-02
• Last updated: 2025-06-10

Locations

1 site across 1 country: United States