NCT02084043

In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation

In Vitro Comparison of Continuous and Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation: Analysis of Inhaled and Lost Doses.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University Hospital St Luc, Brussels · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Using an adult lung bench model of non invasive ventilation, the aim of the study is to compare an experimental system of breath-synchronized vibrating mesh nebulizer to a conventional vibrating mesh nebulizer during non invasive ventilation in terms of inhaled and lost doses.

Conditions

• Respiratory Diseases
• Lung Diseases
• Cystic Fibrosis
• COPD
• Asthma

Interventions

Type	Name	Description
DRUG	Nebulization of Amikacin during NIV (RR: 15 cycles/minute)	500 mg/4 mL Amikacin nebulized using vibrating mesh nebulizer associated with a single limb bilevel ventilator. The nebulizations are considered as finished when there is no visible evidence of nebulization for a period of 30 seconds. The NIV is set with an IPAP of 15 cmH2O and EPAP of 5 cmH2O. The lung model is simulated with a respiratory rate of 15 cycles/minute
DRUG	Nebulization of Amikacin during NIV (RR: 25 cycles/minute)	500 mg/4 mL Amikacin nebulized using vibrating mesh nebulizer associated with a single limb bilevel ventilator. The nebulizations are considered as finished when there is no visible evidence of nebulization for a period of 30 seconds. The NIV is set with an IPAP of 15 cmH2O and EPAP of 5 cmH2O. The lung model is simulated with a respiratory rate of 25 cycles/minute

Timeline

• Start date: 2014-03-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2014-03-11
• Last updated: 2015-06-08

Locations

1 site across 1 country: Belgium