NCT01976975

Brain Mechanisms of Human Motivation

Multi Level Analysis of Positive Valence Systems Across Mood Disorders

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 270 (actual)
• Sponsor: Mclean Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.

Detailed description

The study involves five sessions. In the first session, participants will play a computer task. In the second session, participants will go through a clinical interview and will have an EEG recording while playing another computer task. In the third session, participants will undergo an fMRI scan while playing another computer task. All tasks assess reward learning. At three and six months after the final session, participants will come back for a follow-up interview session during which a clinician will assess symptom severity. There will be no intervention in this study.

Conditions

• Major Depressive Disorder
• Bipolar Disorder

Timeline

• Start date: 2013-10-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2013-11-06
• Last updated: 2021-08-04
• Results posted: 2019-04-23

Locations

1 site across 1 country: United States